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pentobarbital will reduce the extent or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Individuals who transfer to buprenorphine very long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers should be monitored to guara